Abstract This paper describes the performance of flexible pavement using KENLAYER and Highway Development Management (HDM-4) software for urban roads. study includes area four-lane two-lane roads at Hyderabad city, such as Gandi Maissama to Bachupally (GB), Nizampet (BN), Miyapur Bachuapally (MB), JNTU Pragathi Nagar (JP). The distress data like rutting, fatigue, pothole, patches, edge drop eac...

atopic dermatitis (ad) is a heterogeneous disease with regard to clinical phenotype and natural history. we investigated t cell subtypes and cytokine responses in peripheral blood and skin lesions of ad patients with various sensitivities. immunological studies were performed in 27 subjects: 9 house dust mite (hdm)-sensitized; 6 subjects with sensitizations other than hdm; 7 non-allergic ad pat...

There are studies reporting food sensitization in infancy increases the risk of sensitization to inhalants later in life. We performed a study to evaluate whether cosensitization with buckwheat (BW) has an effect on the production of house dust mite-IgE. C3H/HeJ mice (4 weeks, female) were sensitized with house dust mite (HDM)/Al (OH)(3), intraperitoneally on day 0, followed by 4 intranasal sen...

respiratory virus infection is a major cause of asthma exacerbation. however, the underlying mechanisms of  this exacerbation  are unknown. therefore,  to  determine  the mechanisms, we examined the effect of influenza infection in a murine model of asthma.mice were divided into four groups: the phosphate-buffered saline (pbs), house dust mite (hdm), influenza, and hdm/influenza groups. the inf...

The in vitro activity of a host defense peptidomimetic (HDM-4) was investigated. The compound exhibited an antimicrobial activity profile against a range of Gram-negative bacteria. HDM-4 permeabilized the outer membrane and partly depolarized the inner membrane at its minimal inhibitory concentration (MIC). Moreover, it was demonstrated that HDM-4 was distributed widely in the bacterial cell at...

Rapid growth in a number of vehicles on roadways accelerates pavement deterioration trends. Pavement inefficiency in carrying the applied load from passing vehicles results in spending significant costs on continues Maintenance and Rehabilitation (M&R) treatments. Lane closure owing to the implementation of M&R operations incurs enormous costs on road users. The research aimed to calculate, and...

BACKGROUND Tight junction (TJ) defects have recently been associated with asthma and chronic rhinosinusitis. The expression, function, and regulation of nasal epithelial TJs remain unknown in patients with allergic rhinitis (AR). OBJECTIVE We investigated the expression, function, and regulation of TJs in the nasal epithelium of patients with house dust mite (HDM)-induced AR and in an HDM-ind...